Control Ab, Anti-PD-1, 1 each Item ID: PMJ1201

PD-1, PD-L1, PD-1/PD-L1, bioassay, immune checkpoint, immunotherapy, blocking antibodies, therapeutic antibodies, antibody screening, biologics, potency, stability, neutralizing antibody assay, NAb assay, DiscoverX, BPS Biosciences, reporter bioassay, luciferase reporter bioassay, functional bioassay, j1201

Control Ab, Anti-PD-1for use with the PD-1/PD-L1 Blockade Bioassay.

PD-1 is an immune inhibitory receptor expressed on activated T cells and B cells and plays a critical role in regulating immune responses to tumor antigens and autoantigens. Engagement of PD-1 by either of its ligands, PD-L1 or PD-L2, on an adjacent cell inhibits TCR signaling and TCR-mediated proliferation, transcriptional activation and cytokine production. Therapeutic antibodies and Fc fusion proteins designed to block the PD-1/PD-L1 interaction show promising results in clinical trials for the treatment of a variety of cancers. Control Ab, Anti-PD-1 is a control antibody for blocking PD-1 for use with the PD-1/PD-L1 Blockade Bioassay, a biologically relevant MOA-based assay that can be used to measure the potency and stability of antibodies and other biologics designed to block the PD-1/PD-L1 interaction.