CelVivo
In Vitro Technologies has partnered with CelVivo to bring you the latest technology in 3D cell culture.
3D Cell Culture Technology - Mimicking In Vivo Performance
Introducing the innovative and novel CelVivo System for 3D cell culture to bring you unlimited tissue models.
The CelVivo system creates an environment which promotes the growth and maintenance of large 3D tissue mimetic structures, whether they are spheroids, organoids and other aggregates. The technology CelVivo has developed to grow cells so they retain or recover their in vivo physiological attributes.
Application in Focus: Hepatotoxicity
The ClinoStar in vitro 3D organoid culture system that can be used for determining drug toxicity. Click here to learn how you can use the ClinoStar system for toxicology studies as well as:
• Watch a recorded webinar on 3D liver models for liver toxicity studies
• Ask us for a demo of the ClinoStar system
Understanding the CelVivoTechnology
CelVivo’s ambition is to provide cells with conditions which allow them to develop functionality which closely mimics that seen in the intact organism.
To achieve this, they have developed a system which obviates the need for scaffolds, gels or any type of additives which might perturb gene expression away from its natural baseline equilibrium. Furthermore they have very significantly reduced contact with plastics and reduced shear forces. It is possible to use the culture media that you normally use for cell culture. CelVivo suggests reducing glucose levels to 1 g/L glucosw, which is more relative to those seen in healthy animals.
The CelVivo System components
- Clinostar™ System,
- Clinoreactors
- Tablet to control the system.
The ClinoStar is a clinostat for 3D cell culture incorporated in a CO₂ incubator . Allowing you to culture cells in 3D in a single unit.
A tablet is used to control the temperature, CO₂ level and each of the 6 clinostat motors are (independently) controlled using an intuitive software. The CO₂ and temperature in the chamber is blended by a centrally located fan to ensure a precise, homogeneous growth environment.
Learn how the Clinostar principle works
The Advantages of using Clinostats for culturing cells
- Large spheroids are created with high uniformity in size
- Excellent for co-cultures and tumor studies
- The cells experience very low shear stress
- Active diffusion which allow good nutrient exchange.
- The function, architecture and ultrastructure of the spheroid mimics that see in vivo after 3 weeks
Applications and Research Areas
The technology created by CelVivo allows generation of uniform, reproducible and functional spheroids and organoids. These spheroids mimic the function, structure and architecture of in vivo cells. Our technology isn’t merely “3D cell culture”, it lets customers perform research using cell models with an unprecedented correlation between in vivo and in vitro conditions, and closes the gap between 2D cell culture and cell function.
Brochures / Publications
Understanding the CelVivo Technology (Brochure)
For the Latest Publications using CelVivo click Find out more.
Podcasts / More Information
For the Latest Podcasts by Stephen Fey, Chief Research Officer and Co-founder at Celvivo click Find out more
To get more info on how CelVivo’s Clinostar can grow organoids or spheroids that mimic the function, structure, and architecture of in vivo cells, click Find out more
Links and Other Resources
To learn more about 3D Cell Culture
We also offer other products to aid your work with organoids/spheroids
