The extracellular matrix (ECM) consists of an organized, complex network of locally secreted macromolecules that provide the structural framework for cell migration, adhesion, proliferation, and differentiation within the tissues of an organism. The ECM is composed primarily of different glycosaminoglycans and fi brous proteins, such as collagen, laminin, and fi bronectin. The fi brous proteins of the ECM regulate cell structure, adhesion, and medi-ate interactions within the ECM, while the glycosaminoglycans (GAGs), such as hyaluronan or protein-linked GAGs, form a porous hydrated gel that is essential for mechanical support and signal-ing between cells. The properties of isolated ECM components or heterogeneous extracts can be exploited for use as cell culture re-agents and tools for cell-based assays.
R&D Systems offers the Cultrex Basement Membrane Extract (BME) products and ECM components as cell culture reagents that can be used to promote and maintain a variety of cell types in culture, including 2D, 3D in vitro studies and 3D in vivo studies
Corning® Extracellular Matrix Proteins include biological and synthetic products for 2D and 3D cell culture. These ECMs provide a wide range of animal, human, and synthetic ECMs for researchers to support improved cell attachment, propagation, differentiation, and migration.