As a global leader in blood component, therapeutic apheresis and cellular technologies, Terumo BCT believes in the potential of blood to do even more for patients than it does today. As cell therapy advances toward commercialization, the demand for a consistent and effective product increases. A reproducible cell culture process is critical to meeting this demand because it can enable researchers to more efficiently produce a consistent, clinically relevant therapeutic dose, which is essential to the successful development and commercialization of their product. The Quantum is an automated platform designed to simplify the open, labor-intensive tasks associated with manual cell culture.
The Quantum process is functionally closed, reproducible and scalable. The flexible system allows your cell culture process to be optimized and configured to match the needs of your particular cell type. Quantum maintains a consistent and controlled environment, automating critical processes such as feeding cells, removing waste and exchanging gases until it is time to harvest your cells.
The Quantum system's 3-D, functionally closed bioreactor contains about 11,500 hollow fibers with a surface area of 2.1 m2. The large surface area is designed to maximize adherent cell expansion in a minimal amount of space. The Quantum system has the highest cell culture surface-area-to-volume ratio of any closed, automated cell expansion system on the market.
From existing DC maturation processes to newer CAR T-cell therapies, cell separation is playing a major role in the fast-growing fields of research and product development. The Elutra system can be the answer when your process requires cell separation. Elutra uses counterflow elutriation to separate cells on the basis of their size and density. Using both size and density as separation factors increases the resolution of cell separation compared to what is achieved with traditional centrifugation.
From time-tested deglycerolization procedures to bone marrow processing, the COBE 2991 cell processor has been a solid solution for a variety of procedures for washing and concentrating cellular components. The COBE 2991 cell processor offers an alternative to labor-intensive methods for the separation of cell products, such as manually layering blood over a density gradient separation medium using conical tubes. Automated processing puts control at the user's fingertips. Protocols can be easily programmed for efficient, reproducible results while saving time and reducing the number of manual operating steps. For maximum flexibility, nearly all aspects of operation can be controlled manually. Intuitive operation saves training time, requires little technical support and reduces the opportunity for operator errors.
Built on a legacy of proven Terumo BCT welders, the SCD IIB and TSCD-Q welders have the capability to create both wet-to-dry and dry-to-dry tubing connections in just a few simple steps. These compact, portable welders allows operators to connect two pieces of tubing for a variety of operations, such as component transfers, sampling and fluid replacement, while maintaining a functionally closed system in open labs and production areas. The SCD IIB can weld PVC and C-flex tubing, while the TSCD-Q can weld polyurethane tubing.